Situated on the Avenue of the Arts, Southstar Lofts is located just a short distance from major healthcare and educational institutions including Thomas Jefferson University Hospital, Pennsylvania Hospital, the University of the Arts and the Philadelphia High School for Creative and Performing Arts.

In addition, the building is located adjacent to the Broad Street Subway Line, which offers easy transportation to Temple University, Hahnemann University Hospital and The Philadelphia Navy Yard, home to Urban Outfitters, Inc., Glaxo Smith Kline, WuXi AppTec, Inc. and Penn Capital, among other top area employers.